A positive feedback loop of SIRT1 and miR17HG promotes the repair of DNA double-stranded breaks
نویسندگان
چکیده
منابع مشابه
RecBCD enzyme and the repair of double-stranded DNA breaks.
The RecBCD enzyme of Escherichia coli is a helicase-nuclease that initiates the repair of double-stranded DNA breaks by homologous recombination. It also degrades linear double-stranded DNA, protecting the bacteria from phages and extraneous chromosomal DNA. The RecBCD enzyme is, however, regulated by a cis-acting DNA sequence known as Chi (crossover hotspot instigator) that activates its recom...
متن کاملThe Role of Long Non Coding RNAs in the Repair of DNA Double Strand Breaks
DNA double strand breaks (DSBs) are abrasions caused in both strands of the DNA duplex following exposure to both exogenous and endogenous conditions. Such abrasions have deleterious effect in cells leading to genome rearrangements and cell death. A number of repair systems including homologous recombination (HR) and non-homologous end-joining (NHEJ) have been evolved to minimize the fatal effe...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2019
ISSN: 1538-4101,1551-4005
DOI: 10.1080/15384101.2019.1641388